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Your Position: Home > R-Spondin 3

R-Spondin 3

Brief Information

Name:R-spondin-3
Target Synonym:Thrombospondin Type-1 Domain-Containing Protein 2,Thrombospondin, Type I, Domain Containing 2,Protein With TSP Type-1 Repeat,PWTSR,R-Spondin 3 Homolog (Xenopus Laevis),R-Spondin 3 Homolog,R-Spondin-3,CRISTIN1,HRspo3,FLJ14440,Roof plate-specific spondin-3,RSPO3,hPWTSR,THSD2,R-Spondin 3
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:0
Lastest Research Phase:Preclinical

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Cat. No. Species Product Description Structure Purity Feature
RS3-H5253 Human Human R-Spondin 3 / RSPO3 Protein, Fc Tag
RS3-H5253-structure
RS3-H5253-sds
RS6-H5222 Human Human R-Spondin 3 / RSPO3 (22-146) Protein, His Tag
RS6-H5222-structure
RS6-H5222-sds
ACRO Quality

Part of Bioactivity data

RS6-H5222-SPR
Human_FcRn_Heterodimer_Protein_SPR

Human R-Spondin 3 (22-146), His Tag (Cat. No. RS6-H5222) with immobilized on CM5 Chip can bind Human LGR5, His Tag (Cat. No. LG5-H52H3) with an affinity constant of 18.6 nM as determined in a SPR assay (Biacore 8K) (Routinely tested).

Protocol
RS3-H5253-ELISA
Human R-Spondin 3 Protein, Fc TagHuman R-Spondin 3 Protein, Fc Tag (Cat. No. RS3-H5253) ELISA bioactivity

Immobilized Human R-Spondin 3 Protein, Fc Tag (Cat. No. RS3-H5253) at 5 μg/mL (100 μL/well) can bind Human LGR4, His Tag (Cat. No. LG4-H52H3) with a linear range of 0.02-0.625 μg/mL (QC tested).

Protocol

Synonym Name

RSPO3,CRISTIN1,PWTSR,THSD2

Background

R-Spondin 3 (RSPO3) is also called cysteine-rich and single thrombospondin domain containing-1 (CRISTIN1), Protein with TSP type-1 repeat (PWTSR), is a member of the R-spondin protein family. R-spondins (RSPO) are a recently discovered secretory protein family with four members in human and mouse. Although all four RSPO proteins activate the canonical Wnt pathway, RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. RSPO-3 is expressed ubiquitously and expressed at higher level in placenta, small intestine, fetal thymus and lymph node. RSPO3 is the activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. RSPO3 acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. RSPO3 also acts as a ligand for frizzled FZD8 and LRP6 and may negatively regulate the TGF-beta pathway.

Clinical and Translational Updates

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